Gea introduces industrial-scale equipment for production of vaccines and blood plasma

The photo shows the final formulation procedure. This process has two steps. An Ultra-Diafiltration and the following conception stride. The product is Immunoglobulin. Photograph - BLICKPUNKT PHOTODESIGN/Daniel Bödeker

GEA has developed numerous innovative improvements to both claret fractionation and vaccine production and brought them to the global market by applying first-form engineering.

Fractionating homo blood plasma yields purified and concentrated proteins from which drugs or vaccines are and so developed. The blood plasma fractionation process is circuitous and requires in-depth cognition of both the process and the specific equipment needed to achieve high yields in a price-effective timeframe. In the fight against coronavirus, for case, the administration of antibodies to counter Sars-CoV-2 is a promising treatment option. One time someone has been infected with a virus and recovers, their claret is rich with antibodies. Like a vaccine, giving antibody infused blood plasma to a sick patient could speed up their recovery. The advantage, specially for immunocompromised patients, is that the antibodies have already been produced. The downside, however, is the absolute requirement for a sufficient number of willing donors.

However, whether a vaccine induces antibiotic production or they're obtained from claret plasma, both approaches ultimately have one thing in common. Once the laboratory work and clinical tests have been completed, full-scale product must exist expedited to manufacture the largest possible quantities. GEA, the globally agile mechanical and establish engineering visitor with a long history of vaccine and blood fractionation expertise, is ready to quickly transform developments made past pharmaceutical and biotechnology companies into marketable processes and systems.

GEA engineering science for blood plasma fractionation

Claret fractionation refers to the process of separating the plasma obtained from claret into its individual components. Plasma is the liquid function of the blood and accounts for almost 55% of the total book. Information technology consists mainly of water and contains small amounts of dissolved minerals, salts, iron, nutrients and proteins. It serves as a transport and storage medium for erythrocytes (red claret cells), leukocytes (white blood cells) and thrombocytes (blood platelets).

The design, construction and installation of an integrated fractionation plant is an extremely complex and challenging undertaking. It'due south not merely a thing of only connecting various unit operations, it also requires the precise control of parameters including pH, ethanol content and temperature. Equally important is the use of suitable virus inactivation steps and the consummate automation and validation of the entire organisation. With individual machines or modules that tin can be combined and automated to ensure maximum flexibility, high yields, efficient and reliable operation for a long service life, GEA is committed to developing and supplying customer-oriented solutions. The company's extensive experience in establish-specific process implementation has been proven during the final 20 years with the successful completion of endless projects for many clients.

Technologies for global vaccine product

GEA is also a world leader in the design and configuration of microbial and prison cell fermentation systems for the vaccine industry. Supplying standalone modular technologies that can be combined to form an entire production constitute, these GEA solutions are based on all-encompassing expertise in cell civilisation systems, cell separators, homogenization plant and filtration units.

Furthermore, GEA'south spray- and freeze-drying technologies assist innovative technology companies to develop temperature-stable claret products and vaccine preparations that have a long shelf-life and do not require refrigeration, making them easier to transport to hard-to-accomplish and remote areas.

For many years, GEA has been working closely with the world'due south largest vaccine manufacturers. GEA is also an active partner of many other companies in the Developing Countries Vaccine Manufacturers Network (DCVMN) around the world to support the prophylactic and reliable product of cost-effective vaccines.

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